I didn't log on for several weeks. First I browsed through this entire section.
Here are some remarks.
The original idea behind the Space Shuttle: that the entire operation will be much cheaper, being reusable. That has miserably failed for many different reasons.
Opposed to some other posters who indicated that political issues shouldn't be included are wrong, because they are included. They are, because financial reasons play a major role in the space program. Obama even made some remarks about the possible downscaling of the space program. The country is currently not in a financial shape to research the origin of the universe and other, mostly theoretical and/or philosophical issues, costing billions.
Return to the Moon? Why? For a few more bags of rocks? Anyone could claim any other reasonable possibilities? A Moon base? Give me a break. The ISS, since its inception, is basically spending most of its time to keep the thing going, repair what is broken, being put together. For more than a decade (and it is not done). And it is "right next door", not on the Moon. Go to the Mars by 2050? Give me even more break. Yes, we have the technology that people could go there, but we don't to bring them back. Surely, there is no reason for a mission which hauls 3 people there, out of which 2 would land on Mars, collect some sand/rocks and come back. What else promising is there what some robot couldn't currently do?
Surely, they won't be able to take some vehicle, which would allow them to roam the planet for weeks, months and do some proper research. Which would aim exactly for what at this point? We safely know that there is no developed life there. So what if they find some microbe, besides some highly theoretical answer we would get? Life elsewhere exists? Whoopi doo. Then what?
In my not so humble opinion, mankind is kind of stuck on planet Earth, and while its curiosity may one day take it to Mars, even some moons of the Jupiter or Saturn, all are likely to be practical dead end streets. To think outside of our solar system at this point is science fiction. For any such serious thoughts mankind would have to INVENT a totally new means of propulsion. Unfortunately, even a near speed of light vehicle wouldn't allow much outside of our solar system exploration. Thus we can only hope for some currently unknown law of physics which one day allows mankind to travel true galactic distances.
In the meanwhile we are stuck in Earth orbit.